diff --git a/letta/server/db.py b/letta/server/db.py
index fc2fa3e2..17a564ed 100644
--- a/letta/server/db.py
+++ b/letta/server/db.py
@@ -1,5 +1,6 @@
 import os
 import threading
+import uuid
 from contextlib import asynccontextmanager, contextmanager
 from typing import Any, AsyncGenerator, Generator
 
@@ -165,6 +166,15 @@ class DatabaseRegistry:
             if not is_async:
                 base_args["pool_use_lifo"] = settings.pool_use_lifo
 
+        elif is_async:
+            base_args.update(
+                {
+                    "prepared_statement_name_func": lambda: f"__asyncpg_{uuid.uuid4()}__",
+                    "statement_cache_size": 0,
+                    "prepared_statement_cache_size": 0,
+                }
+            )
+
         return base_args
 
     def _wrap_sqlite_engine(self, engine: Engine) -> None: